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Changes of hormonal status in young mice by restricted caloric diet. Relation to lifespan extension. Preliminary results
Authors:W Pierpaoli
Institution:(1) Medizinische Abteilung, Schweizerisches Forschungsinstitut, CH-7270 Davos, (Switzerland);(2) Present address: Cell Biology Division, Institute of Anatomy, University of Zürich, Gloriastrasse 19, CH-8006 Zürich, Switzerland
Abstract:Summary The maintainance of mice on a reduced caloric diet for 6 weeks starting from weaning time produces persistent changes in their hormonal status as reflected by differences in blood levels of gonadal and adrenal steroids. The changes might express a permanently different hypothalamic regulation. This might accoutn for a prolongation of their life span.This work has been supported by the Swiss National Fund for Scientific Research, grant No. 3.8750.72. I thank Miss M. Hämmerli of Ciba-Geigy AG, Basel, for her participation in the low caloric diet experiments.
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