Coenzym B12 als gemeinsamer Wasserstoffüberträger der Dioldehydrase- und der Methylmalonyl-CoA-Mutase-Reaktion |
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Authors: | J Rétey D Arigoni |
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Institution: | (1) Organisch-chemisches Laboratorium der Eidg. Technischen Hochschule, Zürich, Schweiz |
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Abstract: | Summary Tritiated -(dimethylbenzimidazolyl)-Co-5 deoxyadenosyl-cobamide, as obtained in the propanediol dehydrase reaction from (RS)-1-3H-propane-1, 2-diol, is shown to transfer substantial amounts of radioactivity to the substrate when used as a catalyst for the reversible enzymatic conversion of methylmalonyl-CoA to succinyl-CoA. Thus, both reactions involve an intermolecular transfer of hydrogen which is mediated by the same site of the coenzyme. |
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