| 茶多酚对裸鼠喉鳞癌的抑制作用及机制研究 |
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| 引用本文： | 刘阳,赵莉琳,骆文龙.茶多酚对裸鼠喉鳞癌的抑制作用及机制研究[J].世界科技研究与发展,2011,33(5):901-903. |
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| 作者姓名： | 刘阳 赵莉琳 骆文龙 |
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| 作者单位： | [1]重庆医科大学附属第二医院耳鼻咽喉头颈外科,重庆400010 [2]重庆医科大学附属第一医院口腔科,重庆400016 |
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| 摘 要： | 目的观察萘多酚对裸鼠喉鳞癌的抑制作用，并初步探讨其机制。方法将接种Hep22细胞后的裸鼠随机分为4组，其中对照组8只，每天给予生理盐水1ml灌胃；茶多酚高、中、低剂量组各8只，每天分莉给予茶多酚80、160、320mg／kg。20d后处死。分离肿瘤测量其体积，real—time RT—PCR法检测肿癌组织中Src、HK Ⅱ mRNA的表这。己糖激酶活性测定试剂盒测定肿瘤组织中己糖激酶活性。结果茶多酚能硬显降低肿瘤体积，降低肿瘤组织中Src、HK Ⅱ mRNA的表达和己糖激酶活性。结论茶多酚能抑制裸鼠喉鳞癌的生长，其机制可能与抑制肿瘤糖酵解有关。
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| 关 键 词： | 茶多酚 Src HK Ⅱ 糖酵解 |
Inhibition of Tea Ployphenol on Growth of Implanted larynx Squamous Carcinoma in Athymic Mouse |
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| LIE Yang,ZHAO Lilin,LUO Wenlong.Inhibition of Tea Ployphenol on Growth of Implanted larynx Squamous Carcinoma in Athymic Mouse[J].World Sci-tech R & D,2011,33(5):901-903. |
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| Authors: | LIE Yang ZHAO Lilin LUO Wenlong |
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| Institution: | 1. Otolaryngology Head and Neck Surgery,The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010; 2. Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016) |
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| Abstract: | Objective To investigate the effect of Tea ployphenol on implanted larynx squamous carcinoma in athymic mouse.Methods Athymic mouse implanted Hep22 cells were divide into control group and three Tea ployphenol groups （80,160,320 mg/kg.d）. Contents of Src and HK Ⅱ mRNA were detected by real-time RT-PCR methods. The bulk and HK enzyme activity, of tumor were measured. Results In Tea ployphenol groups, Contents of Src and HK Ⅱ mRNA, the bulk and HK enzyme activity of tumor were decreased markedly. Conclusion Tea polyphenol could inhibit the implanted squamous carcinoma in athymic mouse. The mechanism maybe that tea ployphertol could inhibit glycolysis in tumor. |
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| Keywords: | tea ployphenol Src HK Ⅱ glycolysis |
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