Bicarbonate and chloride transport across rat ileal basolateral membrane |
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Authors: | M Tosco M N Orsenigo A Faelli |
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Institution: | (1) Dipartimento di Fisiologia e Biochimica Generali, Università di Milano, via Celoria 26, I-20133 Milano, (Italy) |
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Abstract: | The mechanisms of HCO
3
–
and Cl– transport across basolateral membranes from rat ileum were investigated in isolated vesicles by means of uptake experiments. Neither Cl–/HCO
3
–
exchanger nor Na+–(HCO
3
–
)n cotransport seem to be present in ileal basolateral membranes. Moreover Cl– uptake is unaffected bycis Na+ and/or K+ gradients, indicating the absence of Na+–Cl–, K+–Cl– and Na+–K+–2Cl– symport activity. An electrically conductive pathway seems to be responsible for both HCO
3
–
and Cl– fluxes. Evidence is also given for the presence of a Na+/H+ exchanger at the basolateral pole of ileal enterocytes. |
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Keywords: | Rat ileum basolateral membrane vesicles bicarbonate and chloride transport |
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