| 聚乙烯醇/聚丙烯酰胺水凝胶基小口径人工血管材料 |
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| 引用本文： | 吴雨芬,邢美毅,王璐,关国平.聚乙烯醇/聚丙烯酰胺水凝胶基小口径人工血管材料[J].东华大学学报(自然科学版),2020(1):60-67,74. |
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| 作者姓名： | 吴雨芬 邢美毅 王璐 关国平 |
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| 作者单位： | 东华大学纺织学院;东华大学纺织面料技术教育部重点实验室 |
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| 基金项目： | 上海市教育委员会科研创新资助项目(15ZZ032,ZX201503000017);中央高校基本科研业务费专项资助项目(2232015A3-02);纺织面料技术教育部重点实验室开放课题资助项目(KLTST201611);高等学校学科创新引智计划(111计划)资助项目(B07024);硕士研究生学位论文创新基金资助项目(EG2018009)。 |
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| 摘 要： | 结合浇注法及编织法制备了一种编织管增强的聚乙烯醇(PVA)/聚丙烯酰胺(PAAm)水凝胶小口径人工血管材料(内直径6 mm),并进行了一系列表征。结果表明:当该人工血管材料的拉伸伸长率为50%时,拉伸强度可达到(905.6±63.1)kPa,压缩弹性回复率为(93.4±6.7)%,缝合线固位强力为(9.89±0.64)N;在80~120 mmHg条件下,径向顺应性达到(3.11±0.09)%,是商用e-PTFE人工血管的6.9倍;材料的细胞相容性良好,溶血率极低,属于不溶血材料。
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| 关 键 词： | 水凝胶 人工血管 编织管 力学性能 生物相容性 |
Small Diameter Vascular Grafts Materials Based on Polyvinyl Alcohol/Polyacrylamide Hydrogel |
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| WU Yufen,XING Meiyi,WANG Lu,GUAN Guoping.Small Diameter Vascular Grafts Materials Based on Polyvinyl Alcohol/Polyacrylamide Hydrogel[J].Journal of Donghua University,2020(1):60-67,74. |
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| Authors: | WU Yufen XING Meiyi WANG Lu GUAN Guoping |
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| Institution: | (a.College of Textiles,Ministry of Education,Donghua University,Shanghai 201620,China;Key Laboratory of Textile Science&Technology,Ministry of Education,Donghua University,Shanghai 201620,China) |
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| Abstract: | A polyvinyl alcohol(PVA)/polyacrylamide(PAAm)hydrogel small diameter vascular graft reinforced by a braided strut(with 6 mm inner diameter)was prepared and characterized comprehensively.The results show that tensile strength reaches(905.6±63.1)kPa when axial tensile strain is 50%,the elastic recovery rate can reach as high as(93.4±6.7)%,the suture retention strength is(9.89±0.64)N at the same time.The dynamic radial compliance gets to(3.11±0.09)% which has achieved 6.9 times higher than that of commercial e-PTFE vascular graft under test pressures of 80120 mmHg.The material has good cytocompatibility and low hemolysis rate.It is a hemolytic material. |
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| Keywords: | hydrogel vascular graft braided strut mechanical property biocompatibility |
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