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Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia |
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| Authors: | Noa Tal Chen Shochat Ifat Geron Dani Bercovich Shai Izraeli |
| Affiliation: | 1. Cancer Research Center, Sheba Medical Center, Edmond and Lily Safra Children’s Hospital, Tel Hashomer, 52621, Ramat Gan, Israel 2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 3. Migal Galilee Technology Center, Kiryat Shmona, Israel 4. Tel Hai College, 12210, Upper Galilee, Israel 5. Division of Biological Sciences and Department of Medicine Stem Cell Program, University of California San Diego, La Jolla, California, USA |
| Abstract: | Cancer is often caused by deregulation of normal developmental processes. Here, we review recent research on the aberrant activation of two hematopoietic cytokine receptors in acute lymphoid leukemias. Somatic events in the genes for thymic stromal lymphopoietin and Interleukin 7 receptors as well as in their downstream JAK kinases result in constitutive ligand-independent activation of survival and proliferation in B and T lymphoid precursors. Drugs targeting these receptors or the signaling pathways might provide effective therapies of these leukemias. |
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