| 新的NS配体CYCA的合成、~(99m)Tc标记及动物分布的研究 |
| |
| 引用本文： | 苗玉斌,何千舸,周守明.新的NS配体CYCA的合成、~(99m)Tc标记及动物分布的研究[J].北京师范大学学报(自然科学版),1999(4). |
| |
| 作者姓名： | 苗玉斌 何千舸 周守明 |
| |
| 作者单位： | 北京师范大学化学系!１００８７５，北京 |
| |
| 摘 要： | 为了探索结构与生物分布性质的关系，合成了一种新的ＮＳ配体Ｌ－半胱氨酸酞－对氯苯胺盐酸盐（ＣＹＣＡ）．以ＳｎＣｌ２为还原剂，制备了放化纯大于９３％的９９ｍＴｃＯ－ＣＹＣＡ．探讨了ｐＨ值和反应温度对９９ｍＴｃＯ—ＣＹＣＡ标记率的影响，并对其小鼠生物分布进行了研究．结果表明，９９ｍＴｃｄ－ＣＹＣＡ在脑和心肌中具有一定的浓集，在肝脏中有较高浓集，并且清除速度较慢．这些结果对于探索结构与生物分布性质的关系提供了参考．
|
| 关 键 词： | ~(99m)TcO灌注显像药物 ~(99m)TcO－CYCA 配体结构 SnCl_2还原剂 动物分布性质 |
SYNTHESIS OF A NEW NS LIGAND OF CYCA,PREPARATION AND PRELIMINARY BIODISTRIBUTION OF ~(99m)-TcO-CVCA IN MICE |
| |
| Miao Yubin, He Qiange, Zhou Shouming.SYNTHESIS OF A NEW NS LIGAND OF CYCA,PREPARATION AND PRELIMINARY BIODISTRIBUTION OF ~(99m)-TcO-CVCA IN MICE[J].Journal of Beijing Normal University(Natural Science),1999(4). |
| |
| Authors: | Miao Yubin He Qiange Zhou Shouming |
| |
| Abstract: | in culer to investigate the relationship between ligand structure and biodistributionproperty of 99m-TcO complex, a new NS ligand of CYCA is synthesis. Its WeTed complex isprepaids using stannous chloride as reluctant. The radiochemical purity of 99mTcO- CYCA ismere than 93%. The effects of PH and reaction temperature on labelling yield are investigated.Biodistribution of 99m-TcO-CYCA in de indicateS that certain uptake is demonstrated inbrain and heart, the activity level in liver is high and the aCtivity is cleatal slowly from liver.This study may be valuable to investigation of the relationship between ligand structure andbiodistribution property of 99m-TcO complexes. |
| |
| Keywords: | 99mTcO perfusion haging agent 99mTcO- CYCA ligand structure SnCl2 asreductant biodistribution property |
| 本文献已被 CNKI 等数据库收录！ |
