含席佛碱杯[4]芳烃衍生物的合成及其抗紫外抗氧化活性

为研究抗紫外抗氧化性能为一体的功能有机物,设计合成含席佛碱片段的杯4]芳烃衍生物4,用1HNMR、13C NMR、IR及MS((Maldi-Tof))表征新化合物的结构.研究4在波长280~400 nm范围内的紫外光谱,用DPPH.法测定4对自由基的清除率.结果表明,4在325 nm处有明显的紫外吸收,有抗UVA活性;它对DPPH.的清除率达到34%,有一定的抗氧化活性.实验还发现,4的中间体5,11,17,23-四叔丁基-25,27-二羟基-26,28-二(酰肼基甲氧基)杯4]芳烃3对自由基清除率很高,可达90%左右.

Synthesis and its anti-ultraviolet, anti-oxidation activity of calix[4] arene derivative containing Schiff-base fraction

For developing the functional organic compound with anti-ultraviolet and anti-oxidation activity simultaneously,calix 4] arene derivative containing Schiff-base fraction 4 was designed and synthesized.The structure of 4 was confirmed by 1HNMR,13CNMR,IR and MS(Maldi-Tof).Ultraviolet absorption spectrometry at range of 280-400 nm and the efficiency of radical scavenging of 4 were tested.The results showed that 4 demonstrated anti solar UVA activity due to its obvious ultraviolet absorption at 325nm and a certain anti-oxidation activity for the efficiency of radical scavenging of 34%.It's also found that compound 3,4,5,11,17-tert-butyl-25,27 dihydroxyl-26,28 di(hydrazide group methoxyl) calix4]arene,the intermediate of 4,was with high efficiency of radical scavenging about 90%.