Aktive und passive Immunisierung gegen heterologe Tumoren

Summary Heterologous transplantation of tumors is made possible by pretreatment of the recipients with X-rays or Cortisone. Using the transplantation of the mouse Crocker sarcoma S180 on young rats, active or passive immunisations hinder the growth of these tumors even though the hosts were pretreated with Cortisone or X-rays. Acquired immune bodies seem to play a most important role in the destruction of heterologous tumors. Of minor significance are natural resistance, inflammatory reaction, formation of granulation and fibrous tissue. The influence of Cortisone and X-rays on heterologous tumor transplants consists in suppressing immune body formation. Once immune bodies are formed, Cortisone and X-rays have no effect on their action. Passive transfer of transplantation immunity was made by transplanting lymphnodes, draining the tumor implant.

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Die Arbeit wurde mit Hilfe des Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung durchgeführt.