Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations |
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Authors: | Jean-No?l Bastie Romain Aucagne Nathalie Droin Eric Solary Laurent Delva |
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Affiliation: | Faculté de Médecine, Inserm UMR 866, Université de Bourgogne, 7 bd Jeanne d'Arc, 21000, Dijon, France. |
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Abstract: | The relatively homogenous clinical features and poor prognosis of chronic myelomonocytic leukemia (CMML) are associated with a molecular heterogeneity, with various mutations impacting several convergent pathways. Due to the restricted understanding of the mechanism involved in leukemogenesis, CMML still appears as a diagnostic and therapeutic undertaking, and poor prognosis of leukemia. Contrary to chronic myelogenous leukemia, BCR-ABL1-positive, cytogenetic, and molecular abnormalities of CMML are not specific and not pathognomonic, confirming the different levels of heterogeneity of this disease. Various mutations can be associated with a common phenotype not distinct at the clinical level, further demonstrating that molecular probings are needed for choosing individual targeted therapies. |
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