碘海醇的制备工艺优化

以5-硝基-N，N’-双（2，3-二羟丙基）-1，3．苯二甲酰胺为原料，通过还原、碘代、酰化、烷基化反应制备碘海醇．优化了合成工艺中碘代反应和烷基化反应步骤：在碘代反应中，用碘化钾为碘源、亚氯酸钠为氧化剂代替氯化碘作为碘化试剂；在N-烷基化反应中，用二乙二醇甲醚代替1，2．丙二醇．探讨了物料比、温度等因素对反应的影响，确定了最佳反应条件，总收率达49．4％，产品结构经光谱确证．

Optimization of the Preparation of Iohexol

With 5-nitro-N, N＇-bis （2, 3-dihydroxypropyl）-1 and 3-benzene dicarboxamide as raw material, iohexol was obtained through reduction, iodo, acylation, and alkylation. The steps of Iodination and alkylation reaction in the synthesis reaction were optimized： In the iodination, potassium iodide was used as a source of iodine and sodium chlorite was used as iodination reagent in place of iodine chloride; in N- alkylation reaction, diethylene glycol ether was used in place of 1,2-propylene glycol. The effects of material ratio and temperature on the reaction were explored and the optimum reaction conditions were determined. The total yield was 49.4% and the prodluct structure was confirmed by means of spectral composition.