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Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk |
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| Authors: | Dunlop Malcolm G Dobbins Sara E Farrington Susan Mary Jones Angela M Palles Claire Whiffin Nicola Tenesa Albert Spain Sarah Broderick Peter Ooi Li-Yin Domingo Enric Smillie Claire Henrion Marc Frampton Matthew Martin Lynn Grimes Graeme Gorman Maggie Semple Colin Ma Yusanne P Barclay Ella Prendergast James Cazier Jean-Baptiste Olver Bianca Penegar Steven Lubbe Steven Chander Ian Carvajal-Carmona Luis G Ballereau Stephane Lloyd Amy Vijayakrishnan Jayaram Zgaga Lina Rudan Igor Theodoratou Evropi;Colorectal Tumour Gene Identification Consortium Starr John M Deary Ian Kirac Iva |
| Institution: | Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council (MRC) Human Genetics Unit, Edinburgh, UK. malcolm.dunlop@hgu.mrc.ac.uk |
| Abstract: | We performed a meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer (CRC) risk comprising 8,682 cases and 9,649 controls. Replication analysis was performed in case-control sets totaling 21,096 cases and 19,555 controls. We identified three new CRC risk loci at 6p21 (rs1321311, near CDKN1A; P = 1.14 × 10(-10)), 11q13.4 (rs3824999, intronic to POLD3; P = 3.65 × 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC. |
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