Specific binding of antigenic peptides to cell-associated MHC class I molecules |
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Authors: | I F Luescher P Romero J C Cerottini J L Maryanski |
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Affiliation: | Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland. |
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Abstract: | T lymphocytes recognize antigen in the form of peptides that associate with specific alleles of class I or class II major histocompatibility (MHC) molecules. By contrast with the clear MHC allele-specific binding of peptides to purified class II molecules purified solubilized class I molecules either bind relatively poorly or show degenerate specificity. Using photo-affinity labelling, we demonstrate here the specific interaction of peptides with cell-associated MHC class I molecules and show that this involves metabolically active processes. |
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