| 小鼠胸腺瘤细胞程式死亡调控的初步研究 |
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| 引用本文： | Jenk.,EJ 戴玲.小鼠胸腺瘤细胞程式死亡调控的初步研究[J].安徽大学学报(自然科学版),1993,17(2):72-77. |
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| 作者姓名： | Jenk. EJ 戴玲 |
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| 摘 要： | 通过对小鼠胸腺瘤细胞的筛选,获得了具T_(cR)V_~+CD4~+CD_~+表型的CD11.3-D_2细胞株,钙离子载体lonomycin能够诱导其死亡,而抗CD_3单克降抗体却不能介导它死亡,CD11.3-D_23细胞可作为研究细胞程式死亡(Programmed Cell Death)机理和胸腺细胞发育分化机理的体外模型.
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| 关 键 词： | 小鼠胸腺瘤细胞株 细胞程式死亡 钙离子载体 |
Studies on the Regulation of Cell Death in Thymoma Cell Line |
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| Abstract: | CD11. 3-D-2 cell line is a mice thymoma with an immature phenotype (CD_4~+CD_8~+) and bears T_(cR)a V_(?) chain which can be detected by McAbs. It can be induced to undergo apoptotic death by calcium ionophone, but is refractory to death mediated by anti-T_(cR)/CD_3 antibody. Since the mechanisms behind apoptotic death are not yet fully understood, this cell line could be used as a system to study programmed cell death. |
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| Keywords: | thymoma apoptosis calcium ionophore |
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