| 新型单羰基姜黄素类似物的合成及抗肿瘤活性研究 |
| |
| 引用本文： | 周代营,田宇光,杜志云,赵肃清,郑希,张焜.新型单羰基姜黄素类似物的合成及抗肿瘤活性研究[J].华南师范大学学报(自然科学版),2014,46(3):82-0. |
| |
| 作者姓名： | 周代营 田宇光 杜志云 赵肃清 郑希 张焜 |
| |
| 作者单位： | 1.1.广东食品药品职业学院 |
| |
| 基金项目： | 国家自然科学基金项目(B0207&21272043);广州市第一批菁英计划留学项目(11YB02) |
| |
| 摘 要： | 采用氮烷基化、羟基保护、醛酮缩合三步反应合成了8个新型单羰基姜黄素类似物，结构经质谱、核磁共振氢谱和核磁共振碳谱等手段进行确认。并采用MTT染色法体外检测所合成的8个单羰基姜黄素类似物对人肺癌细胞H1299，结肠癌细胞HT-29，人体胰腺癌细胞BxPC-3和人前列腺癌细胞PC-3的抗癌活性。半数抑制浓度IC50值结果显示:所合成的8个姜黄素类似物对四种细胞均有较强的抑制作用，其中化合物A6在四种细胞中的半数抑制浓度IC50均在0.65 μM以下，抗癌活性比姜黄素提高了40倍以上。
|
| 关 键 词： | 抗肿瘤活性 |
| 收稿时间： | 2014-01-17 |
Synthesis and Anti-tumor Properties of Mono-carbonyl Curcumin Analogues |
| |
| Zhou Daiying;Tian Yuguang;Du Zhiyun;Zhao Suqing;Zheng Xi;Zhang.Synthesis and Anti-tumor Properties of Mono-carbonyl Curcumin Analogues[J].Journal of South China Normal University(Natural Science Edition),2014,46(3):82-0. |
| |
| Authors: | Zhou Daiying;Tian Yuguang;Du Zhiyun;Zhao Suqing;Zheng Xi;Zhang |
| |
| Institution: | Zhou Daiying;Tian Yuguang;Du Zhiyun;Zhao Suqing;Zheng Xi;Zhang Kun;Guangdong Food and Drug Vocational College;Guangdong University of Technology; |
| |
| Abstract: | Eight Mono-carbonyl curcumin analogues were synthesized by three-step reaction of alkylation, hydroxyl protection, aldehyde ketone condensation. Their structures were characterized by 1H NMR and ESI-MS techniques. Then all the compounds were synthesized and evaluated for their effects on cultured prostate cancer PC-3 cells, pancreas cancer BxPC-3 cells, colon cancer HT-29 cells and lung cancer H1299 cells. These compounds exhibited potent inhibitory effects on the growth of cultured PC-3, BxPC-3, HT-29 and H1299 cells. The IC50 for A6 was lower than 0.65μM in all four cell lines, and A6 was 40-fold more active than curcumin. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《华南师范大学学报(自然科学版)》浏览原始摘要信息 |
| 点击此处可从《华南师范大学学报(自然科学版)》下载免费的PDF全文 |
