A possible chemical basis for the higher mutagenicity of marijuana smoke as compared to tobacco smoke |
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| Authors: | M Novotny M L Lee K D Bartle |
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| Institution: | (1) Department of Chemistry, Indiana University, 47401 Bloomington, Indiana, USA;(2) Present address: Department of Physical Chemistry, University of Leeds, Leeds, (England) |
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| Abstract: | Summary The results of comparative analyses of polynuclear aromatic hydrocarbons in marijuana and tobacco smoke indicate a considerably higher content of potential carcinogens in the former. A model experiment involving  9-tetrahydrocannabinol suggests that the pyrolysis products of cannabinoids are major contributors to the polynuclear aromatic hydrocarbons.We thank Dr.John Benner and Ms.Carolyn Keene of the University of Kentucky for help with the smoking experiments. This work was supported by Grant No. R01-DA-00507-01 from the National Institute of Mental Health. |
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