Zum Problem des Stoffwechsels der Brenztraubensäurein vivo

Summary Following intravenous injection of pyruvic acid (PA) in the form of the sodium salt in the normal rabbit the level of PA in the blood rises, falling again to the initial level after 60 minutes. In the case of the alloxandiabetic animal the elimination of PA administered in equal doses is markedly retarded. If animals are used that suffer from a progredient alloxan diabetes leading to death in coma, an increased endogenous hyperpyruviæmia can be demonstrated. Insulin plays no part in the regulation of PA metabolism; through the application of aneurin, however, one succeeds in enabling the organism to make use of PA. A separate report will deal with the complex relations holding in endogenous hyperpyruviæmia in coma.

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Der Großteil der Experimente wurde mit Unterstützung der Roche-Studienstiftung durchgeführt.