Kank proteins: structure, functions and diseases |
| |
Authors: | N Kakinuma Y Zhu Y Wang B C Roy R Kiyama |
| |
Institution: | (1) Signaling Molecules Research Group, Neuroscience Research Institute, National Institute of Advanced Industrial Science and Technology, AIST Central 6, 1-1-1 Higashi, Tsukuba Ibaraki, 305-8566, Japan |
| |
Abstract: | The Kank family of proteins, Kank1–Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal
region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found
by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways
containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal
and developmental disorders, will be an important subject of future study. |
| |
Keywords: | Ankyrin-repeat Coiled-coil motif Tumor suppressor gene Actin stress fiber Nucleo-cytoplasmic shuttling Renal cell carcinoma Signal transduction |
本文献已被 SpringerLink 等数据库收录! |
|