5-Hydroxytryptamine binding to butanol extracts from myelin fragments |
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Authors: | R Ishitani A Miyakawa R Saito T Iwamoto |
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Institution: | (1) Department of Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 350-02 Sakado, Saitama, Japan |
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Abstract: | Summary The myelin fraction of rat brain stem was treated with butanol-water mixtures, and the extracted proteolipids were separated by Sephadex LH20 column chromatography. 2 peaks of proteolipids eluted in chloroform-methanol 4/1 showed the binding capacity for C14·5-HT. This finding suggests the necessity of the more careful investigations for the probability of proteolipids as receptor proteins in the central nervous system. |
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