Antithyroid effect of a food or drug preservative: 4-hydroxybenzoic acid methyl ester |
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| Authors: | B. Rousset |
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| Affiliation: | (1) Laboratoire de Médecine Expérimentale, Faculté de Médecine Alexis Carrel, FRA INSERM No. 30, rue Guillaume-Paradin, F-69008 Lyon, (France) |
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| Abstract: | Summary 4-hydroxybenzoic acid methyl ester (methylparaben) inhibits organification of iodide by isolated hog thyroid cells. The concentration which produces a 50% inhibition was about 2.0×10–4M. A similar inhibition was observed in nonstimulated and TSH- or dibutyryl cyclic AMP-stimulated cells. Neither iodide uptake nor cyclic AMP generation were altered by methylparaben. |
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