Functions of actin in endocytosis |
| |
Authors: | Alastair S Robertson Elizabeth Smythe Kathryn R Ayscough |
| |
Institution: | (1) Department of Molecular Biology and Biotechnology, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK;(2) Department of Biomedical Science, University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK; |
| |
Abstract: | Endocytosis is a fundamental eukaryotic process required for remodelling plasma-membrane lipids and protein to ensure appropriate
membrane composition. Increasing evidence from a number of cell types reveals that actin plays an active, and often essential,
role at key endocytic stages. Much of our current mechanistic understanding of the endocytic process has come from studies
in budding yeast and has been facilitated by yeast’s genetic amenability and by technological advances in live cell imaging.
While endocytosis in metazoans is likely to be subject to a greater array of regulatory signals, recent reports indicate that
spatiotemporal aspects of vesicle formation requiring actin are likely to be conserved across eukaryotic evolution. In this
review we focus on the ‘modular’ model of endocytosis in yeast before highlighting comparisons with other cell types. Our
discussion is limited to endocytosis involving clathrin as other types of endocytosis have not been demonstrated in yeast. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|