Improved treatment of organophosphate intoxication by use of scopolamine or dexetimide |
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| Authors: | U Bertram A Kasten H Lüllmann A Ziegler |
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| Institution: | (1) Department of Pharmacology, University of Kiel, Hospitalstrasse, 4-6, D-2300 Kiel, (Federal Republic of Germany, BRD) |
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| Abstract: | Summary Organophosphate intoxications have been treated by dexetimide plus obidoxime. Rabbits intoxicated by the 50-80fold LD50 of different organophosphates survived. Prophylactic application of dexetimide or scopolamine plus obidoxime increased the LD50 of DFP by a factor up to 180.Supported by the Fraunhofer-Gesellschaft e. V., Munich, BRD |
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