Designing CD4 immunoadhesins for AIDS therapy |
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| Authors: | D J Capon S M Chamow J Mordenti S A Marsters T Gregory H Mitsuya R A Byrn C Lucas F M Wurm J E Groopman |
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| Affiliation: | Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080. |
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| Abstract: | A newly-constructed antibody-like molecule containing the gp120-binding domain of the receptor for human immunodeficiency virus blocks HIV-1 infection of T cells and monocytes. Its long plasma half-life, other antibody-like properties, and potential to block all HIV isolates, make it a good candidate for therapeutic use. |
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