Membrane traffic in the secretory pathway |
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| Authors: | J Malsam S Kreye T H Söllner |
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| Institution: | (1) Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA;(2) Present address: Merck & C. Inc., 126 E. Lincoln Ave, P.O. Box 2000, Rahway, NJ 07065, USA;(3) Present address: Reata Pharmaceuticals, Inc., 2801 Gateway Drive # 150, Irving, TX 75063, USA; |
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| Abstract: | SNARE (SNAP receptor) proteins drive intracellular membrane fusion and contribute specificity to membrane trafficking. The
formation of SNAREpins between membranes is spatially and temporally controlled by a network of sequentially acting accessory
components. These regulators add an additional layer of specificity, arrest SNAREpin intermediates, lower the energy required
for fusion, and couple membrane fusion to triggering signals. The functional activity of some of these regulators determines
the plasticity of regulated exocytosis. (Part of a Multi-author Review) |
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