Activation and inactivation of thyroid hormone by deiodinases: Local action with general consequences |
| |
Authors: | B Gereben A Zeöld M Dentice D Salvatore A C Bianco |
| |
Institution: | (1) Laboratory of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary;(2) Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli ”Federico II”, Naples, Italy;(3) Thyroid Section, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Room 643,77 Avenue Louis Pasteur, Boston, MA 02115, USA |
| |
Abstract: | The thyroid hormone plays a fundamental role in the development, growth, and metabolic homeostasis in all vertebrates by affecting
the expression of different sets of genes. A group of thioredoxin fold-containing selenoproteins known as deiodinases control
thyroid hormone action by activating or inactivating the precursor molecule thyroxine that is secreted by the thyroid gland.
These pathways ensure regulation of the availability of the biologically active molecule T3, which occurs in a time-and tissue-specific
fashion. In addition, because cells and plasma are in equilibrium and deiodination affects central thyroid hormone regulation,
these local deiodinase-mediated events can also affect systemic thyroid hormone economy, such as in the case of non-thyroidal
illness. Heightened interest in the field has been generated following the discovery that the deiodinases can be a component
in both the Sonic hedgehog signaling pathway and the TGR-5 signaling cascade, a G-protein-coupled receptor for bile acids.
These new mechanisms involved in deiodinase regulation indicate that local thyroid hormone activation and inactivation play
a much broader role than previously thought.
Received 29 August 2007; received after revision 11 October 2007; accepted 16 October 2007 |
| |
Keywords: | Thyroid hormone metabolism deiodinases non-thyroidal illness syndrome obesity Sonic hedgehog pathway bile acid |
本文献已被 PubMed SpringerLink 等数据库收录! |
|