Nucleoside-specific tolerance suppresses anti-nucleoside antibody forming cells |
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Authors: | Stollar B D Borel Y |
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Affiliation: | Department of Biochemistry and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. |
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Abstract: | Since its original development by Jerne, the haemolytic plaque assay has increased our understanding of antibody formation to a wide variety of antigens, including proteins, lipopolysaccharides, and simple haptens. We have now developed an assay to detect plaque forming cells (PFC) making anti-nucleoside antibodies. Previously we reported the suppression of circulating antibody to DNA determinants by nucleoside-IgG conjugates. Here we show that BALB/c mice can be rendered tolerant in terms of both direct and indirect anti-nucleoside antibody forming cells and that the state of tolerance is nucleoside-specific at the cellular level. |
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