山大颜Psychotria sp.中皂苷类化合物研究

继续对山大颜具有抗肿瘤活性的乙酸乙酯部分进行活性成分分离,得到4个三萜及其苷类化合物。采用物理常数对照和现代波谱分析技术及化学方法对其结构进行研究,确定其为:Psychotrianosides G(1)、Ardisianosides D(2)、β-香树脂醇(3)、豆甾醇-3-O-β-D-葡萄糖苷(4)。将化合物2水解得到Cyclamiretin A(5)。化合物1为首次得到的天然产物,首次采用2D NMR技术对其NMR数据进行全归属。所有化合物均首次从九节属中得到。

Saponins from the Stem of Psychotria sp.

To continue to study anti-tumour bioactive saponins EtOAc layer from methanol extract of the stem of psychotria sp., four compounds were obtained by all kinds of column chromatography, such as silica gel, Sephdex LH-20, and ODS. Their structures were characterized by spectroscopy including NMR, MS, GC MS analyses, and chemical and the physical methods. The result indicated that they were Psychotrianosides G (1), Ardisianosides D (2),β-amyrin (3), and Stigmasterol 3-O-β-D glycosidase(4). Cyclamiretin A (5) was obtained by acid hydrolysis of 2. Psychotrianosides G(1) was firstly obtained as a natural product. The chemical structure of compound (1) was analyzed by 2D NMR firstly. Compounds 1,2,3,4,5 were firstly obtained from genus of psychotria.