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| 基于UFLC-Q-TOF-MS/MS技术的盐酸克林霉素棕榈酸酯分散片杂质的研究 | |
| 引用本文： | 黄昕,张超,周翠兰,邹威,苏薇薇,彭维.基于UFLC-Q-TOF-MS/MS技术的盐酸克林霉素棕榈酸酯分散片杂质的研究[J].中山大学学报(自然科学版),2014,53(4):101-106. |
| 作者姓名： | 黄昕 张超 周翠兰 邹威 苏薇薇 彭维 |
| 作者单位： | 1.中山大学生命科学学院，广东 广州510275； 2.广州一品红制药有限公司，广东 广州510760 |
| 基金项目： | 广东省科技计划资助项目(2012B090600020) |
| 摘 要： | 采用UFLC-Q-TOF-MS/MS技术,在正离子模式下,根据各物质的质谱裂解规律,研究鉴定出盐酸克林霉素棕榈酸酯分散片中16种杂质,其中克林霉素九酸酯、克林霉素十酸酯、克林霉素十一酸酯、克林霉素十三酸酯为首次检到,本研究为其质量监控提供了实验依据。 |
| 关 键 词： | 盐酸克林霉素棕榈酸酯分散片 杂质 液质联用分析 |
| 收稿时间： | 2014-01-06; |
Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS |
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| HUANG Xin,ZHANG Chao,ZHOU Cuilan,ZOU Wei,SU Weiwei,PENG Wei.Analysis of Impurities in Clindamycin Palmitate Hydrochloride Dispersible Tablets Through UFLC-Q-TOF-MS/MS[J].Acta Scientiarum Naturalium Universitatis Sunyatseni,2014,53(4):101-106. | |
| Authors: | HUANG Xin ZHANG Chao ZHOU Cuilan ZOU Wei SU Weiwei PENG Wei |
| Institution: | 1. School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China； 2.Guangzhou Yipinhong Pharmaceutical Company Limited，Guangzhou，510760，China |
| Abstract: | Sixteen impurities in clindamycin palmitate hydrochloride dispersible tablets were identified according to their fragmentation patterns and characteristic fragment ions by UFLC-Q-TOF-MS/MS in a positive mode. Among them, clindamycin nonanoate, clindamycin decanoate, clindamycin monodecanoate, clindamycin tridecanoate were firstly detected. These results provided a basis for quality control of clindamycin palmitate hydrochloride dispersible tablets. |
| Keywords: | clindamycin palmitate hydrochloride dispersible tablets impurities LC-MS analysis |
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