The binding of tritiated dexamethasone to lymphocytes of normal and leukemic subjects]

Specific binding sites for 3H-dexamethasone, possessing the characteristics of glucocorticoid receptors, were demonstrated in normal human circulating lymphocytes. The number of glucocorticoid receptors was found different from normal in half of the acute or chronic lymphoid leukaemias studied. A correlation between the number of glucocorticoid receptors and the therapeutical benefit of the glucocorticoid administration will be performed, including these preliminary observations.