The influence of MuLV and SV40 viruses on senescence in mouse fibroblasts in vitro |
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| Authors: | R S U Baker |
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| Institution: | (1) Radiation Biology Laboratory, School of Public Health and Tropical Medicine, University of Sydney, Building A27, 2006 Sydney, N. S. W., Australia |
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| Abstract: | Summary Mouse cells productively infected with Moloney leukaemia virus (MuLV) underwent senescence in a manner similar to control cells, although they recovered more readily as an established line. Rapidly growing cell lines were also obtained following simian virus 40 (SV40) infection of senescent cells. However, superinfection of senescent MuLV-producing cells by SV40 led to slower growing cells with a reduced output of infectious MuLV. |
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