Effects of intracellular or extracellular application of tetraethylammonium on the action potential in cultured chick embryonic heart muscle cell |
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| Authors: | Y Maruyama E Yamashita H Inomata |
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| Institution: | (1) Department of Applied Physiology, Tohoku University School of Medicine, Seiryo-cho 2-1, 980 Sendai, (Japan);(2) Miyagi College of Education, Aramaki Aoba-mubanchi, 980 Sendai, (Japan) |
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| Abstract: | Summary The effects of tetraethylammonium (TEA) on the action potential in cultured chick embryonic heart muscle cells were investigated. The onset of prolongation of the action potential occurred within 10 min following intracellular iontophoretic application of TEA, but after more than 50 min following extracellular application. These facts suggest that the major site of action of TEA is on the inner surface of the membrane in these cells. |
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