| 配体叠合的蛋白质结合部位结构多样性的分析 |
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| 引用本文： | 陈辉,黄积涛.配体叠合的蛋白质结合部位结构多样性的分析[J].天津理工大学学报,2005,21(5):8-11. |
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| 作者姓名： | 陈辉 黄积涛 |
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| 作者单位： | 1. 天津理工大学,材料物理所,天津,300191
2. 天津理工大学,生物与化学工程学院,天津,300191 |
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| 基金项目： | 天津市高等学校科技发展基金资助项目（99705）. |
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| 摘 要： | 蛋白质结构与功能间关系的一个重要方面是蛋白质与配体的识别和结合能力问题.本文通过探寻与同一个配体（HEM）相作用的74个非同源蛋白质上活性位点的潜在规律来分析蛋白质的结构,综合应用编程、数据处理及图像分析等手段对蛋白质及配体的叠合进行研究,为用3D-QSAR方法研究蛋白质的结构提供了可能.
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| 关 键 词： | 结构叠合 活性位点 配体 3D-QSAR |
| 文章编号： | 1673-095X（2005）05-0008-04 |
| 收稿时间： | 2005-03-02 |
| 修稿时间： | 2005-03-02 |
Structural diversity of protein binding sites based on superposition of the ligands |
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| CHEN Hui,HUANG Ji-tao.Structural diversity of protein binding sites based on superposition of the ligands[J].Journal of Tianjin University of Technology,2005,21(5):8-11. |
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| Authors: | CHEN Hui HUANG Ji-tao |
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| Institution: | 1. Institute of Material Physics, Tianjin University of Technology, Tianjin 300191, China; 2. School of Bioteehnology and Chemieal Engineering, Tianjin University of Teehnology, Tianjin 300191, China |
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| Abstract: | One important aspect in correlation between structure and function is the ability of recognition and bond between proteins and ligands.Protein structure is analyzed in this thesis through studying the underlying law of 74 non-homologous protein binding sites bond with the same ligand(HEM).The superposition between protein and ligand is studied by means of programming,data processing and image analyzing,so it provides a kind of possibility to study proteins with the method of 3D-QSAR. |
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| Keywords: | structural superposition active site ligand 3D-QSAR |
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