Pentobarbital: Presynaptic effect in the squid giant synapse |
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| Authors: | K. G. Morgan S. H. Bryant |
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| Affiliation: | (1) Dept. of Pharmacology, College of Medicine, University of Cincinnati, 45267 Cincinnati, Ohio, USA;(2) Present address: Department of Physiology and Biophysics, Mayo Medical School, 55901 Rochester, Minnesota, USA |
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| Abstract: | Summary In concentrations that produced synaptic blockade in the squid giant synapse, sodium pentobarbital produced a dose-related, reversible decrease of the  calcium spike of the presynaptic terminal.This work was performed while Dr Morgan was a Grass Foundation Fellow at the Marine Biological Laboratory, Woods Hole, Massachusetts, USA.The authors thank Dr J. Z. Yeh for the loan of the 4-aminopyridine and Dr G. H. Acheson for helpful suggestions. |
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