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Lack of effect of dihydroergotamine on endothelial and smooth muscle cell proliferation and endothelial cell prostanoid production |
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| Authors: | B Lindblad W E Burkel T W Wakefield L M Graham J C Stanley |
| Institution: | (1) Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA;(2) Department of Anatomy and Cell Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA;(3) Present address: Department of Surgery, University of Lund, Malmö General Hospital, S-21401 Malmö, Sweden |
| Abstract: | Summary The most important effect of dihydroergotamine is venoconstriction, but certain metabolic effects and changes in vessel prostanoid activity have also been suggested. In this study endothelial cell production of 6-keto PGF1 and TxB2 was quantitated in vitro. No evidence of altered prostanoid production was noted after incubation with dihydroergotamine (exposure ranging from 5×10–3 to 5×10–7 g/l). Similarly, no effect of dihydroergotamine on the growth rates of endothelial cells or smooth muscle cells in vitro was documented. |
| Keywords: | Dihydroergotamine endothelial cells smooth muscle cell prostanoid production |
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