| 钆基无机纳米粒子磁共振造影剂设计的研究进展 |
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| 引用本文： | 赵硕,周治国.钆基无机纳米粒子磁共振造影剂设计的研究进展[J].上海师范大学学报(自然科学版),2022,51(5):667-675. |
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| 作者姓名： | 赵硕 周治国 |
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| 作者单位： | 上海师范大学 化学与材料科学学院, 上海 200234 |
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| 基金项目： | 国家自然科学基金（21877080） |
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| 摘 要： | 磁共振成像（MRI）技术是常见的临床医学影像学的检测手段之一.在临床诊断中使用最多的是纵向弛豫（T1）造影剂：马根维显（Gd-DTPA）.自其正式商用化后，人们对钆基造影剂进行了大量研究.文章介绍了钆基无机纳米粒子（Gd IONPs）造影剂的作用原理，阐述了无机纳米粒子的形貌、尺寸、表面修饰、氧空位等因素的影响，并对Gd IONPs造影剂的设计做了展望.
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| 关 键 词： | 钆基造影剂 磁共振成像(MRI) 纵向弛豫率(r1) 无机纳米粒子 |
| 收稿时间： | 2022/7/15 0:00:00 |
Research progress in the design of gadolinium-based inorganic nanoparticles for magnetic resonance contrast agents |
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| ZHAO Shuo,ZHOU Zhiguo.Research progress in the design of gadolinium-based inorganic nanoparticles for magnetic resonance contrast agents[J].Journal of Shanghai Normal University(Natural Sciences),2022,51(5):667-675. |
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| Authors: | ZHAO Shuo ZHOU Zhiguo |
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| Institution: | College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, China |
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| Abstract: | Magnetic resonance imaging(MRI) is one of the common detection methods in clinical medical imaging. The most commonly used longitudinal relaxation (T1) contrast agent in clinical diagnosis is Gadopentetate Dimeglumine(Gd-DTPA). Since their commercialization, gadolinium-based contrast agents have been studied extensively. This paper introduces the working principle of gadolinium-based inorganic nanoparticle(Gd IONPs) contrast agents, expounds the influence of the morphology, size, surface modification, oxygen vacancy of the inorganic nanoparticles, and looks forward to the design of gadolinium-based inorganic nanoparticle contrast agents. |
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| Keywords: | gadolinium-based contrast agent magnetic resonance imaging(MRI) longitudinal relaxation rate(r1) inorganic nanoparticles |
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