Invertebrate neuropeptides resembling vasotocin and some analogues: Synthesis and pharmacological properties |
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| Authors: | M Kruszyński M Manning N C Wo W H Sawyer |
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| Institution: | (1) Department of Biochemistry, Medical College of Ohio, 43699 Toledo, Ohio, USA;(2) Department of Pharmacology, College of Physicians and Surgeons of Columbia University, 10032 New York, New York, USA;(3) Present address: University of Gdansk, Poland |
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| Abstract: | Summary The solid phase synthesis of three invertebrate vasopressin-oxytocin homologs: AVP-like factor, F1
1, (Leu2, Thr4] AVT)2 isolated from subesophageal and thoracic ganglia ofLocusta migratoria
3, Arg-conopressin-S4. (Ile2, Arg4] AVT), Lys-conopressin-G4 (Phe2, Arg4] LVT), both isolated from the venom of fish-hunting marine snails of the genusConus and six of their analogues is reported. These analogues are: Arg4] AVT, Ile2] AVT, Leu2] AVT, Phe2, Arg4] AVT, Arg4] LVT and Ile2, Arg4] LVT. All peptides were tested for antidiuretic and vasopressor activities. |
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| Keywords: | Conopressins AVT-LVT analogues antidiuretic activity vasopressor activity V2/V1 selectivity |
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