| 放线菌类培养滤液体外自由基清除和抗氧化活性的研究 |
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| 引用本文： | 刘方,陈亮,赵力,王东,李巍,李乐,牛淑敏. 放线菌类培养滤液体外自由基清除和抗氧化活性的研究[J]. 南开大学学报(自然科学版), 2003, 36(3): 105-110 |
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| 作者姓名： | 刘方 陈亮 赵力 王东 李巍 李乐 牛淑敏 |
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| 作者单位： | [1]南开大学生命科学学院微生物系，天津300071 [2]天津医院，天津300211 |
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| 基金项目： | 国家自然科学基金资助项目(30270039)，天津市自然科学基金重点资助项目(023803211) |
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| 摘 要： | 本研究了60种放线菌类培养滤液体外自由基清除和抗氧化活性．这60种放线菌类按阿拉伯数字的顺序被编号．分别采用化学反应抑制自由基产生的化学测定法和抑制红细胞溶血的生物测定法．结果显示2#、41#、45#、52#和54#同时具有高的羟自由基和超氧阴离子的清除活性，以及抑制红细胞溶血能力；36#仅有羟自由基清除活性；44#有超氧阴离子的清除活性，同时有抑制红细胞溶血能力．由此估计抑制红细胞溶血与超氧阴离子的清除活性有关，而与羟自由基清除活性无明显的关系．
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| 关 键 词： | 放线菌 抗氧化 自由基 |
| 文章编号： | 0465-7942(2003)03-0105-06 |
| 修稿时间： | 2003-03-13 |
STUDIES ON FREE RADICAL SCAVENGING AND ANTIOXIDANT ACTIVITIES OF THE CULTURE FILTRATES FROM ACTINOMYCETE IN VITRO |
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| LIU Fang,CHEN Liang,ZHAO Li,WANG Dong,LI Wei,LI Le,NIU Shumin. STUDIES ON FREE RADICAL SCAVENGING AND ANTIOXIDANT ACTIVITIES OF THE CULTURE FILTRATES FROM ACTINOMYCETE IN VITRO[J]. Acta Scientiarum Naturalium University Nankaiensis, 2003, 36(3): 105-110 |
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| Authors: | LIU Fang CHEN Liang ZHAO Li WANG Dong LI Wei LI Le NIU Shumin |
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| Abstract: | Free radical scavenging and antioxidant activities of 60 culture filtrates from actinomycete in vitro were studied. In Arabic numeral order, the number were given to 60 species in actinomycete. Chemical assays were used to determine the inhibitions of free radical generation. Biologic assay was used to determine the inhibition of erythrocytes hemolysis. In the culture filtrates of 60 species, 2# , 41# , 45# , 52# and 54# exhibited the potency in hydrox-yl and superoxide radical scavenging activities, and inhibiting erythrocyte hemolysis. 36# manifested potent hydroxyl radical scavenging activities. 44# had both strong both superoxide radical scavenging activities and inhibiting erythrocyte hemolysis. It was suggested that the inhibiting erythrocyte hemolysis was related to superoxide radical scavenging activities, but not hydroxyl radical scavenging activities. |
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| Keywords: | actinomycete antioxidant free radical |
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