Differential protection of radiation-induced DNA single-strand breaks and cell survival by solcoseryl |
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| Authors: | C P Sigdestad K Weber Doak D J Grdina |
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| Institution: | (1) Present address: Radiation Oncology Department, J. Graham Brown Cancer Center, University of Louisville, 40202 Louisville, Kentucky, USA;(2) Present address: Biology and Medical Research Division, Argonne National Laboratory, 60439 Argonne, IL, USA |
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| Abstract: | Summary V79 Chinese hamster cells were studied in vitro for modification of cobalt-60 gamma radiation effects by solcoseryl. This treatment did not modify cell survival but did protect against DNA single-strand breaks.Solcoseryl is a registered trademark of Solco Basle Ltd, CH-4127 Birsfelden, Switzerland and was kindly supplied by Drs Haigis and Nasrin. In scientific German literature this material is referred to as  Actihaemyl .Supported in part by U.S. Department of Energy Contract No. W-31-109-ENG-38 and NIH/NCI grant No. CA-37435, awarded to D. Grdina, ANL. |
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| Keywords: | Radiation effects in vitro cell survival solcoseryl actihaemyl DNA single-strand breaks radiation protectors |
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