强化制酸及抗焦虑／抑郁治疗糜烂性食管炎疗效分析

目的评价强化制酸及抗焦虑／抑郁联合治疗糜烂性食管炎疗效。方法经标准抗酸疗效不佳并伴有焦虑、抑郁状态的患者41例，随机分为治疗组（n=21）口服奥美拉唑并氟哌塞吨美利曲辛，对照组（n=20）口服给予奥美拉唑及安慰剂。治疗4周后行症状自评、胃镜检查及精神状态评价。结果烧一L,／反酸改善或显效总有效率治疗组显著高于对照组（P〈0．01）；胃镜下食管远段充血及糜烂减轻或改善总有效率治疗组显著高于对照组（P〈0．05）。结论糜烂性食管炎常规治疗无效的患者常伴有焦虑／抑郁。采用强化制酸并抗焦虑／抑郁治疗可有效改善症状，有助于食管粘膜修复。

Effect of therapeutic alliance about strengthening antacid and anti- depression/anxiety on erosive esophagitis

Objective To investigate the effect of therapeutic alliance about strengthening antacid and anti - depression/anxiety on erosive esophagitis. Methods 41 subjects confirmed diagnosis of erosive esophagitis with depression/anxiety and no consequence after anti - acid treatment. Then, randomly divided into experimental group（ n = 21）which oral Omeprazole, Flupentixol and Melitracen tablets, and control group （n = 20） which oral omeprazole and placebo tablets. After 4 weeks treatment, all patients carried out Self- Rating Depression/Anxiety Scale（SDS/SAS）, Gastroscopy and Frequency scale for the symptoms of gastroesophageal reflux disease（ FSSG ）. Results The total effective rate of improved hearthum/water brash significantly rose in experimental group com- pared to control group （80.95% vs35%, P 〈 0.01 ）. With Gastroscopy, the total effective rate of improved con- gestion/erosio of esophageal distal segment was higher in experimental group than that of control group （66.7 % vs25%, P 〈 0.05）. Conclusion It is no useful for the erosive esophagitis patients with depression/anxiety to treat conventionally. Strengthening anti - acids and anti - depression/anxiety therapy may improve these symptoms, and in favor of the esophageal mucous membrane recovery.