Monoaminoguanidine prevents sorbitol accumulation,nonenzymatic protein glycosylation and development of kidney lesions in diabetic rats |
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Authors: | K Kumari P S R Murthy M K Sahib |
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Institution: | (1) Division of Biochemistry and Toxicology, Central Drug Research Institute, 226 001 Lucknow, (India) |
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Abstract: | Summary Monoaminoguanidine administration (25 mg/kg b.wt, i.p. for 14 weeks) to alloxan diabetic rats (blood glucose 250 mg/dl) decreased the nonenzymatic protein glycosylation and sorbitol levels. It prevented development of Armanni-Ebstein tubular lesions, pathological changes in the glomerular capillary tufts and glomerular basement membrane thickening in the kidney.CDRI Communication no. 4694. |
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Keywords: | Monoaminoguanidine alloxan diabetes nephropathy sorbitol nonenzymatic protein glycosylation |
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