细胞钙浓度的变化对周期信号的响应及胞间同步

 钙离子是细胞中一种很重要的第二信使,通常它以钙离子浓度振荡的方式转导多种生理学信息,影响细胞分化、成熟和凋亡等各种生理过程，最终导致生物效应。通过实验研究了细胞钙浓度的变化对周期信号的响应和建立在多细胞模型的基础上，从肝细胞内钙离子振荡的动力学模型出发,以胞间耦合因子作为影响因子，数值分析单细胞、耦合的多细胞下的胞内钙振荡形式。实验结果表明：细胞钙振荡对不同频率和强度的周期信号的响应是不同的：对有的参数周期信号能产生强烈响应，有的不能。数值分析结果表明：细胞间的差异性导致钙振荡不同，胞间耦合影响多细胞钙振荡的同步性。

The Frequency Response of the Cell Calcium Concentration Change and Synchronization

The calcium ion is a mostly important kind of second-messenger which can transmit many physiological-information and affect physiological process such as cell's differentiation、maturation、 apoptosis through calcium oscillation and result in bio-effect. The frequency response of cell calcium concentration change through experiment and based on the multiple cells model given and the nonlinear dynamic model of the calcium oscillation in rat hepatocyte cells, the calcium oscillating behaviors of the single cell, the coupling multi-cell were numerically analyzed, where the coupling coefficient between cells was the influential factor. The experimental results show that the frequency response of cell calcium oscillation was difference: the exposures of electromagnetic waves are divided to two circumstances: the one that lead to certain change, the one is not. The numerical results show that the different cell has the different calcium oscillating behavior, the coupling coefficient between cells influences the synchronization of the calcium oscillation.