| 板兰根、鱼腥草、女贞子和枸杞子抗环磷酰胺引起的骨髓抑制初探 |
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| 引用本文： | 薄芯,赵小民,刘红涛,马文国,李红.板兰根、鱼腥草、女贞子和枸杞子抗环磷酰胺引起的骨髓抑制初探[J].北京联合大学学报(自然科学版),1994(1). |
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| 作者姓名： | 薄芯 赵小民 刘红涛 马文国 李红 |
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| 作者单位： | 北京联合大学职业技术师范学院 |
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| 摘 要： | 本试验以环磷酰胺为阳性药，以嗜多染红细胞微核率为指标探索板兰根、鱼腥草、女贞子和枸杞子保护正常分裂细胞染色体，降低化疗中毒副作用骨髓抑制的作用机理，揭示此４种药均有抗环磷酰胺引起的嗜多染红细胞微核率升高作用，且用药量与疗效间有一定量效关系．此４种中药在临床上可用于降低化疗引起的毒副作用和日常生活中保护正常分裂细胞不受诱变剂影响的抗变保健作用。
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| 关 键 词： | 环磷酰胺，微核率，抗突变，量效关系 |
A Study on 4 Kinds of Chinese Medicines Reducing Arrest of Bone Marrow by Cyclophosphomidum |
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| Bo Xin,Zhao Xiaomin,Liu Hongtao,Ma Wenguo,Li Hong.A Study on 4 Kinds of Chinese Medicines Reducing Arrest of Bone Marrow by Cyclophosphomidum[J].Journal of Beijing Union University,1994(1). |
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| Authors: | Bo Xin Zhao Xiaomin Liu Hongtao Ma Wenguo Li Hong |
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| Abstract: | This experiment used micronucleus(MN) of mice as a marker test the action ofIsatis tinctorza,Houttuynia cordata,Lycium barbarum and Ligustrum lucidum on arrest of bonemarrow by cyclophosphomidum(CP).The results showed that the 4 kinds of Chinesemedicines can reduce the MN rate of polychromatic erythracytes by CP and have mutation re-sistance. And they showed notable dose-effect relationship. |
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| Keywords: | cyclophosphomidum MN rate mutation resistance dose-effect relationship |
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