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Antagonism of V2-receptor effect of antidiuretic hormone by atrial natriuretic peptide in man |
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| Authors: | J Brown M L Forsling G Valdes J D H Slater C T Dollery |
| Institution: | (1) Royal Postgraduate Medical School, Du Cane Road, W12 London, England;(2) Department of Physiology, Middlesex Hospital Medical School, Cleveland Street, W1 London, England;(3) Cobbold Laboratories, Middlesex Hospital, Mortimer Street, W1 London, England;(4) Present address: The Physiological Laboratory, Downing Site, Downing Street, CB2 3EG Cambridge |
| Abstract: | Summary Human  -atrial natriuretic peptide (h-ANP) makes the urine of dehydrated volunteers hypotonic to plasma despite high circulating concentrations of antidiuretic hormone. Urinary dilution with h-ANP also occurs in subjects receiving indomethacin. Therefore, h-ANP antagonises effects of antidiuretic hormone on distal tubular V2-receptors in man, probably without involving prostaglandins. |
| Keywords: | Atrial natriuretic peptide antidiuretic hormone hydraulic conductivity prostaglandins |
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