MicroRNA control of Nodal signalling |
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Authors: | Martello Graziano Zacchigna Luca Inui Masafumi Montagner Marco Adorno Maddalena Mamidi Anant Morsut Leonardo Soligo Sandra Tran Uyen Dupont Sirio Cordenonsi Michelangelo Wessely Oliver Piccolo Stefano |
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Institution: | Department of Histology, Microbiology and Medical Biotechnologies, Section of Histology and Embryology, University of Padua, viale Colombo 3, 35126 Padua, Italy. |
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Abstract: | MicroRNAs are crucial modulators of gene expression, yet their involvement as effectors of growth factor signalling is largely unknown. Ligands of the transforming growth factor-beta superfamily are essential for development and adult tissue homeostasis. In early Xenopus embryos, signalling by the transforming growth factor-beta ligand Nodal is crucial for the dorsal induction of the Spemann's organizer. Here we report that Xenopus laevis microRNAs miR-15 and miR-16 restrict the size of the organizer by targeting the Nodal type II receptor Acvr2a. Endogenous miR-15 and miR-16 are ventrally enriched as they are negatively regulated by the dorsal Wnt/beta-catenin pathway. These findings exemplify the relevance of microRNAs as regulators of early embryonic patterning acting at the crossroads of fundamental signalling cascades. |
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