| 焦脱镁叶绿酸-a甲酯的二氢卟吩色基上的官能团的修饰与保护 |
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| 引用本文： | 武进,刘冉冉,杨泽,王振,王进军.焦脱镁叶绿酸-a甲酯的二氢卟吩色基上的官能团的修饰与保护[J].烟台大学学报(自然科学与工程版),2011(4). |
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| 作者姓名： | 武进 刘冉冉 杨泽 王振 王进军 |
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| 作者单位： | 烟台大学药学院;烟台大学化学化工学院; |
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| 基金项目： | 山东省自然科学基金资助项目(Y2008B49) |
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| 摘 要： | 将叶绿素-a溶解于乙酸并回流,一步剔除中心镁离子和脱去132-位甲氧酰基,再经重氮甲烷甲基化得到焦脱镁叶绿酸-a甲酯,再通过亲电加成、亲电取代、亲核加成、氧化、还原和消去等化学反应,实施对焦脱镁叶绿酸-a甲酯中3-位乙烯基1、31-位羰基、17-位尾端酯基和20-中位氢的活性反应位点,同时,对官能团保护的形成过程进行了探讨,并且提出了可能的反应机理.所得新化合物的化学结构经IR1,HNMR及元素分析予以确定.
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| 关 键 词： | 叶绿素-a 二氢卟吩 脱镁叶绿酸-a甲酯 官能团保护 |
Modification and Protection for Functional Groups on Chlorin Chromophore of Mthyl Pheophorbide-a |
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| WU Jin,LIU Ran-ran,YANG Ze,WANG Zhen,WANG Jin-jun.Modification and Protection for Functional Groups on Chlorin Chromophore of Mthyl Pheophorbide-a[J].Journal of Yantai University(Natural Science and Engineering edirion),2011(4). |
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| Authors: | WU Jin LIU Ran-ran YANG Ze WANG Zhen WANG Jin-jun |
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| Institution: | WU Jin1,LIU Ran-ran2,YANG Ze2,WANG Zhen2,WANG Jin-jun2(1.School of Pharmacy,Yantai University,Yantai 264005,China,2.School of Chemistry and Chemical Engineering,China) |
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| Abstract: | Methyl pyropheophorbide-a is obtained from chlorophyll-a by the reflux in acetic acid for weeding out center magnesium ion and removing carbomethoxyl group in one step and the methylation with diazomethane.The active reaction sites of methyl pyropheophorbide-a,including C3-vinyl group,C132-carbonyl group,terminal C17-carbonmethoxyl group and C20-meso-hydrogen,are protected by electrophilic addition,electrophilic substitution,nucleophilic addition,oxidation,reduction and elimination reactions.The protecting ... |
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| Keywords: | chlorophyll-a chlorin methyl pheophorbide-a protection of functional group |
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