Synthesis of O1.5-(beta-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide, a new highly potent analgesic enkephalin-related glycosyl peptide |
| |
| Authors: | J L Torres I Haro G Valencia F Reig J M García-Antón |
| |
| Affiliation: | Peptide Research Section, Centre d'Investigació i Desenvolupament, C.S.I.C., Barcelona, Spain. |
| |
| Abstract: | A new series of O-glycosyl enkephalins has been prepared, following a convergent strategy, with high chemical yields. The galactosyl analogue, O1.5-(beta-D-galactopyranosyl) [DMet2, Hyp5] enkephalin amide proved to be one of the most potent in vivo opioid agonists synthesized up to now. |
| |
| Keywords: | |
|
|
