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A near-infrared fluorescent probe for fluorine ions and its application in the imaging of HepG2 cells |
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| Authors: | Wei Gong RuiXian Su Lu Li KeHua Xu Bo Tang |
| Affiliation: | GONG Wei,SU RuiXian,LI Lu,XU KeHua & TANG Bo * Key Laboratory of Molecular and Nano Probes of Ministry of Education,Engineering Research Center of Pesticide and Medicine Intermediate Clean Production of Ministry of Education,College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University,Jinan 250014,China |
| Abstract: | In this study, we have designed and synthesized a new near-infrared (NIR) fluorescent probe (BODIPY-Se) to detect fluorine ions (F−) using a B-Se bond to connect the fluorescent dye BODIPY and benzotrifluoride. The probe exhibited a highly selective fluorescence response to F− with a detection limit of 7.4 × 10−8 mol/L. The excitation and emission spectra of the probe in the NIR region avoid background fluorescence interference present in biological systems. The fluorescent imaging of HepG2 cells demonstrated that the newly developed probe should be broadly applicable to detect F− in living cells. |
| Keywords: | near infrared fluorescent probe fluorine ion BODIPY |
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