| 6S-5,6,7,8-四氢叶酸的合成研究 |
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| 引用本文： | 侯学会,王建玲,王国庆,吕全建. 6S-5,6,7,8-四氢叶酸的合成研究[J]. 河南师范大学学报(自然科学版), 2012, 40(3): 108-110 |
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| 作者姓名： | 侯学会 王建玲 王国庆 吕全建 |
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| 作者单位： | 1. 郑州牧业工程高等专科学校质量检测与管理系,郑州,450011
2. 郑州轻工业学院应用化学系,郑州,450002 |
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| 基金项目： | 国家自然科学基金，河南省高校科技创新人才支持计划 |
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| 摘 要： | 报道了一种简单、廉价、安全、适合工业化生产的合成左旋四氢叶酸的方法.采用工业级叶酸为起始原料,通过还原反应、手性拆分等步骤合成了标题化合物,总收率达到38.7%.
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| 关 键 词： | 6S-5,6,7,8-左旋四氢叶酸 还原反应 拆分 |
Process for the Preparation of 6S-5,6,7,8-tetrahydrofolic Acid |
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| HOU Xue-hui , WANG Jian-ling , WANG Guo-qing , LV Quan-jian. Process for the Preparation of 6S-5,6,7,8-tetrahydrofolic Acid[J]. Journal of Henan Normal University(Natural Science), 2012, 40(3): 108-110 |
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| Authors: | HOU Xue-hui WANG Jian-ling WANG Guo-qing LV Quan-jian |
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| Affiliation: | 1(1.Department of Quality Detection and Management,Zhengzhou College of Animal Husbandry Engineering,Zhengzhou 450011,China;2.Department of Applied Chemistry,Zhengzhou University of Light Industry,Zhengzhou 450002,China) |
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| Abstract: | 6S-5,6,7,8-tetrahydrofolic acid is synthesized from commercial available folic acid used as raw materials via reduction reaction and chiral resolution reaction.The overall yield could reach 38.7%(calculated from folic acid).The method has high industrial value thanks to its low production cost,convenient steps,simplicity and high yield. |
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| Keywords: | 6S-5,6,7,8-tetrahydrofolic acid reduction reaction resolution reaction |
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