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| 补充白藜芦醇对大强度运动大鼠心肌损伤的保护作用 | |
| 引用本文： | 武胜奇,张琳,郝选明,熊正英.补充白藜芦醇对大强度运动大鼠心肌损伤的保护作用[J].河南师范大学学报(自然科学版),2012,40(2):140-143. |
| 作者姓名： | 武胜奇 张琳 郝选明 熊正英 |
| 作者单位： | 1. 广东外语艺术职业学院基础部,广州,510640 2. 华南师范大学,广州,510631 3. 陕西师范大学体育学院暨运动生物学研究所,西安,710062 |
| 摘 要： | 目的:探讨RES对大强度运动心肌过氧化损伤的保护作用.方法:在活动跑台上建立大强度运动模型,测试心肌各项过氧化损伤指标.结果:大强度运动可造成大鼠心肌MDA,TNOS,iNOS,NO显著升高,TSOD,CuZn-SOD,GSH-Px,cNOS,Na+,K+-ATPase,Ca2+-ATPase显著下降.补充RES可使大鼠运动后心肌MDA,TNOS,iNOS,NO下降,TSOD,CuZn-SOD,Mn-SOD,GSH-Px,cNOS,Na+,K+-ATPase,Ca2+-ATPase升高.结论:RES可增强心肌的抗氧化能力,保持心肌酶活性.提示RES对大强度运动后心肌过氧化损伤具有保护作用. |
| 关 键 词： | 白藜芦醇 大强度运动 一氧化氮 一氧化氮合酶 ATP酶 心肌 |
Protective Effects of Resveratrol on Exercise-induced Myocardial Damage in Rrats |
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| WU Sheng-qi , ZHANG Lin , HAO Xuan-ming , XIONG Zheng-ying.Protective Effects of Resveratrol on Exercise-induced Myocardial Damage in Rrats[J].Journal of Henan Normal University(Natural Science),2012,40(2):140-143. | |
| Authors: | WU Sheng-qi ZHANG Lin HAO Xuan-ming XIONG Zheng-ying |
| Institution: | 1 Basic Department,Guangdong Teachers’ College of Foreign Languages and Arts,Guangzhou 510640,China; 2.South China Normal University,Guangzhou 510631,China;3 Institute of Physical Education and Institute of Exercise Biology,Shaanxi Normal University,Xi’an 710062,China) |
| Abstract: | Objective:To investigate the protective effects of resveratrol on exercise-induced myocardial damage in rats.Method:Mice were trained on intensive treadmill and indicators of myocardium were detected.Results:Activities of ALT,AST,CK,LDH,ALP in levels of myocardial MDA,total NOS,iNOS,NO increased significantly in rats after intensive exercise;while those of myocardial total SOD,CuZn-SOD,GSH-Px,cNOS,Na+K+-ATPase,Ca2+-ATPase decreased significantly in rats after intensive exercise.The supplement of resveratrol degraded activities of ALT,AST,CK,LDH,ALP in serum and levels of myocardial MDA,total NOS,iNOS,NO after intensive exercise;while raised those of myocardial total SOD,CuZn-SOD,GSH-Px,cNOS,Na+K+-ATPase,Ca2+-ATPase after intensive exercise.Conclusion:The study has demonstrated that resveratrol could enhance myocardial antioxygen and enzymatic activity which suggests the protective effects of resveratrol against exercise-induced myocardial damage in rats. |
| Keywords: | resveratrol intensive exercise nitric oxide nitric oxide synthase ATPase myocardium |
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