Interferon receptors and their role in interferon action |
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| Authors: | S E Grossberg J L Taylor V M Kushnaryov |
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| Institution: | Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226. |
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| Abstract: | Interferon (IFN) proteins interact with cells through specific cell surface receptors, some of which have been purified and cloned. The alpha-IFNs and beta-IFN bind to a common receptor (type I), whereas gamma-IFN binds to a separate receptor (type II). Both types of high-affinity receptors have been demonstrated on a variety of receptors and the ways in which IFNs may affect cellular physiology and gene expression is discussed. |
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